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KMID : 0390320080180010268
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Chungbuk Medical Journal
2008 Volume.18 No. 1 p.268 ~ p.275
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Increased Plasma Thioredoxin in Hemodialysis Patients
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Kwon Soon-Kil
Kim Hye-Young
Kwon Jin-Sook
Bae Jang-Wahn
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Abstract
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Purpose: Thioredoxin, one of the regulators of cellular redox balance plays a protective role for oxidative stress via direct (antioxidant) and indirect (regulation of signal transduction) effects. Also blood thioredoxin is elevated in the condition of oxidative stress. It is not well known that hemodialysis (HD) can cause oxidative stress caused by interdialytic volume change. We decided to study the oxidative stress and left ventricular strain during HD by measuring interdialytic changes of thioredoxin in the same patients.
Materials & Method: Blood thioredoxin levels were determined in 54 HD patients before and after a regular 4 hours of HD. Thioredoxin was measured with sandwich ELISA kit (Redox Bioscience Inc, Kyoto, Japan), blood C-reactive protein and other chemicals for measure inflammatory status of the patients. We also followed the changes of thioredoxin depending on age, sex, duration of HD, and many biochemical parameters.
Results: Post-HD thioredoxin level was significantly increased from 9.98±2.3 ng/ml to 10.93±3.0 ng/ml (p<0.01). Thioredoxin levels were significantly increased after HD in the patients with diabetes (p<0.05), elevated C-reactive protein (CRP) (p<0.01), and more than 5 years of maintenance HD (p<0.01).
Conclusions: Blood thioredoxin levels were significantly increased after HD in the patients with end stage renal disease, and increased in the patients with diabetes, longer duration of HD, elevated CRP. Blood thioredoxin level can reflect oxidative stress and vascular inflammation in the HD patients. We suggest that HD can cause oxidative stress to the patients with end stage renal disease.
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KEYWORD
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Thioredoxin, Hemodialysis, Oxidative stress
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